Clinical Application of Phosphatidylserine

Phosphatidylserine has numerous clinical application cases. The following are some specific examples:

I. Improving Cognitive Function

For the Elderly: Dr. Crook and his colleagues from the Memory Assessment Clinics in the United States conducted a study on 149 voluntary subjects aged between 50 and 75 years old. The subjects took 300 milligrams of phosphatidylserine (divided into three doses of 100 milligrams each) or a placebo every day for 12 weeks. The results showed that after 3 weeks of treatment, there were improvements in the performance of memorizing names and faces, recalling names and faces, and recognizing faces. The researchers further analyzed 57 subjects with more severe memory impairment, with an average age of 64.3 years old. After receiving phosphatidylserine treatment, they showed significant improvements in aspects such as remembering phone numbers, recalling misplaced objects, sentence recall, and their attention during reading, conversation, and performing tasks. Their cognitive abilities seemed to be 12 years younger.

For Children: Japan once conducted a clinical trial on children aged 4 to 14 years old. They were given chewable tablets containing 200 mg of phosphatidylserine every day. After two months of continuous intake, it was found that the short-term memory of the children was significantly improved, and their concentration was also notably enhanced. In another experiment, students were divided into a control group and an intervention group. The intervention group took 250 ml of pure milk fortified with 100 mg of phosphatidylserine every day, while the control group took 250 ml of ordinary pure milk. After 40 days, the scores of each subscale and the total score of the intervention group with phosphatidylserine were significantly higher than those of the control group.

II. Relieving Stress and Anxiety

Some examinees shared their feedback on taking phosphatidylserine: Due to high stress during exam preparation, they had problems such as emotional anxiety, insomnia, and inattentiveness. After taking it for 45 days, their emotions became much more stable, and they wouldn't break down easily. Their bedtime was stabilized at around 11:30 pm, and their concentration also improved. Previously, they couldn't even finish a 40-minute class, but now they could maintain a good study state in the study room for a whole morning. In the study by Hellhammer and others, a social stress test experiment was conducted on subjects using a mixture of soy lecithin and phosphatidylserine (PAS). After taking 400 mg/day of PAS for three weeks, the levels of serum adrenocorticotropic hormone and cortisol in the subjects were significantly inhibited, their physical tension was relieved, and there was no impact on the heart rate.

III. Treating Nervous System Diseases

In the treatment of Alzheimer's disease, phosphatidylserine can inhibit the formation of β-amyloid protein fragments in patients and has a protective effect on nerves. The open clinical trial conducted by the neuroscience research team of Tel Aviv University in Israel found that PS-DHA (phosphatidylserine-docosahexaenoic acid) may be related to the improvement of memory impairment in the elderly.